The Third Colloquium of the IBSE will be held on 14th February 2019. Prof. Michael Knop, Group leader at the Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) and German Cancer Research Institute (DKFZ) Heidelberg, Germany has kindly agreed to be our guest speaker. His laboratory develops software and advanced microscopy methods in biology, and methods for genome engineering in model organisms. He also investigates processes that regulate cellular morphogenesis, cell signalling and protein homeostasis. His research work uses methods from quantitative biology in combination with genetics, deterministic and stochastic simulations, and new instrumentation.