Quantitative and Population Genetics

Instructor: Dr. Himanshu Sinha

Description

To introduce students with concepts and principles of population genetics and methods for identification of genetic loci regulating phenotype in populations.

Course Content

• Introduction to Mendelian genetics
• Genetic constitution of a population - Gene frequencies and genotypes
• Hardy-Weinberg equilibrium
• Changes in gene frequency and continuous variation - Mutation, Selection, Equilibria, Polymorphisms
• Values, means and variance - Metric characteristics, Population means, Genetic components of variation, Genotype and environment correlation, Environmental variance
• Selection: the response and its prediction - Response to selection, Measurement of response, Metric characters under natural selection
• Quantitative trait loci - Major genes, Methods of mapping QTLs, Genetical and statistical considerations
• QTLs in plants, fruit fly, mouse/rats, yeast
• Genomic methods of mapping QTLs
• Haplotype mapping and genome-wide association studies (GWAS)
• QTL interactions: genetic and environment