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Course-ID: BT5440

Quantitative and Population Genetics

Instructor: Dr. Himanshu Sinha

Description

To introduce students with concepts and principles of population genetics and methods for identification of genetic loci regulating phenotype in populations.

Course Content

  • Introduction to Mendelian genetics
  • Genetic constitution of a population - Gene frequencies and genotypes
  • Hardy-Weinberg equilibrium
  • Changes in gene frequency and continuous variation - Mutation, Selection, Equilibria, Polymorphisms
  • Values, means and variance - Metric characteristics, Population means, Genetic components of variation, Genotype and environment correlation, Environmental variance
  • Selection: the response and its prediction - Response to selection, Measurement of response, Metric characters under natural selection
  • Quantitative trait loci - Major genes, Methods of mapping QTLs, Genetical and statistical considerations
  • QTLs in plants, fruit fly, mouse/rats, yeast
  • Genomic methods of mapping QTLs
  • Haplotype mapping and genome-wide association studies (GWAS)
  • QTL interactions: genetic and environment