Modulation of TNFR1 signaling mediated apoptosis response

Abstract:
Cell-to-cell variability during TNFα stimulated Tumor Necrosis Factor Receptor 1 (TNFR1) signaling can lead to single-cell level pro- survival and apoptotic responses. This variability stems from the heterogeneity in signal flow through intracellular signaling entities that regulate the balance between these two phenotypes. In this talk, using systematic Boolean dynamic modeling of a TNFR1 signaling network, modulation of the signal flow path variability to enable cells favour apoptosis will be demonstrated. A computationally efficient approach “Boolean Modeling based Prediction of Steady-state probability of Phenotype Reachability (BM- ProSPR)” to accurately predict the network’s ability to settle into different phenotypes will be presented. Model analysis juxtaposed with the experimental observations to unravel the underlying dynamical cross-talk will be discussed.

Speaker:
Ganesh Viswanathan is a Professor in the Department of Chemical Engineering, Indian Institute of Technology Bombay. Prior to joining IIT Bombay, he was a Postdoctoral Fellow at the Mount Sinai School of Medicine. He completed PhD from University of Houston, Master’s from IISc and B.Tech from CECRI. His currents research interests are in the areas of systems biology and network dynamics.